![]() © 2018 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. The use of flumazenil for reversing midazolam sedation seems to be safe and effective.īenzodiazepines drug-related side effects and adverse reactions flumazenil midazolam. ![]() The time in the recovery room after flumazenil administration was significantly shortened, and the use of the drug did not increase the risk of adverse events or discomfort. Additionally, there were no differences in the patients' memory of the procedure, satisfaction with sedation, willingness to repeat the endoscopy and mental status. Flumazenil, a drug that acts as an antagonist of the benzodiazepine-aminobutyric acid (GABA) receptor complex located in the brain has been proposed to ameliorate HE in the short term. No significant differences were found in the number of patients with pain (VAS ≥1), adverse events and discomfort between the two groups. Supplementary Information The online version contains supplementary material available at 10.1007/s40360-z. Midazolam delivered via other methods or nitrous oxide/oxygen sedation could be considered, but the evidence for both was very low. The length of stay in recovery was significantly shorter in group I than in group II. Oral midazolam is recommended for conscious dental sedation. We asked the patients about their pain and degree of satisfaction according to a visual analogue scale (VAS), their memory of the procedure, mental status and the presence of uncomfortable symptoms on the day of the procedure and the day afterwards. The time of stay in the recovery room and adverse events were reviewed through the nursing records. 10 min after the patient's transfer to the recovery room, and no antidote was injected in group II. In group I, flumazenil was administered i.v. Participants who underwent an upper endoscopy under midazolam sedation were randomly divided into two groups. This study aimed to investigate the safety and efficacy of flumazenil injections after elective endoscopy under midazolam sedation. Midazolam sedation during elective endoscopy is widely performed and flumazenil is frequently administered after endoscopy to reverse sedation in clinical practice.
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